Ameliorative effect of quercetin on pancreatic damage in rodent: a meta-analysis

Pancreatitis has the potential to occur with increasing cases of hyperlipidemia and alcohol consumption. Meanwhile, until now pharmacotherapy for pancreatitis is more emphasized pain relief lowering triglyceride levels (for HFD-induced pancreatitis). The polyphenol (quercetin) several biological activities, including anti-cancer, antiallergic, anti-inflammatory ant-diabetic. This study aimed evaluate effect quercetin treat pancreatitis. After verification, 19 relevant articles were included in analysis, where Linear mix model analysis was applied parameters blood glucose, pancreas islet number, insulin level, TBARS nuclear factor kappa B (NF-κB), endogenous antioxidant (GSH, SOD, CAT, GPx), TNFα, IL−6, Caspase 3 (Casp3) IL−1b gene expression. level used as fixed setting random effect. administration able significantly increase production tissue insulin, restore defense system (increase GSH, decrease TBARS), inhibit progression inflammation based on expression NF-kB, TNFα IL−6 genes. Therefore, results meta-analysis support hypothesis that pancreatic function, be developed